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FDA did not evaluate Crohns disease, celiac disease, or tendonitis under the vote question because the nomination lacked sufficient information and the agency did not identify suitable clinical studies in those populations

Common, usually mild: Injection-site reactions (redness, swelling, itching), most frequent with both Mild headache, dizziness, or flushing after injection Initial water retention as IGF-1 rises Transient fatigue in the first 12 weeks Less common, dose-dependent: Carpal tunnel-like wrist symptoms (sign IGF-1 may be too high) Joint discomfort or stiffness Numbness or tingling in extremities Elevated blood glucose (GH antagonizes insulin) The monitoring that matters:IGF-1 (insulin-like growth factor 1, the downstream marker of GH activity) is the lab value that tells you whether youre in a therapeutic range or pushing past it

However, it may also be used to support weight loss in those overweight dealing with related health conditions

doi: 10.1016/j.jep.2020.112769 18

Heightened inflammation: Dysregulated NF-kB pathways promote pro-inflammatory cytokines

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