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Moreover, the SURMOUNTMMO (tirzepatide, NCT05556512) will assess the impact of the dual GLP-1/GIP RA in cardiovascular outcomes and all-cause mortality for people with obesity (without diabetes) when the REDEFINE-3 study will assess the impact of cagrisema in people with obesity (with and without T2DM) and established cardiovascular disease

In addition to heightened fibroblast activity, which plays a key role in collagen synthesis, tissue repair, and regeneration, there appeared to be a possible rise in mast cell activation