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Kaplan, MD, PhD

There are several possible underlying causes for an increase of histamine in the digestive tract or a decrease of DAO enzyme levels

Tight junctions are composed of transmembrane proteins, primarily Claudins, Occludin, and Junctional Adhesion Molecules (JAMs), which are anchored to the cell's internal cytoskeleton by scaffolding proteins like Zonula Occludens (ZO-1, ZO-2, and ZO-3)

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