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Furthermore, it was demonstrated that exogenous pyruvate, functioning as a complementary substrate, impeded the reduction of fumarate under CB-839 treatment conditions

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The complex's high binding affinity for copper(II) means that GHK can act as a chelator of free copper that might otherwise participate in damaging Fenton-like reactions, sequestering the metal in a form less reactive with cellular targets

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However, combining compounds increases complexity and requires careful oversight

Metallomics 7 , 202211 (2015)