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IL-20 also caused tubular epithelial cells to die and increased mesangial cells production of pro-inflammatory molecules

Proteins are essential for growth, repair, and maintenance of body tissues

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A decrease in IGF-I levels in AD and VD has been widely documented and it may be involved in the development of neurofibrillary tangles, abnormal amyloid metabolism and aberrant Tau phosphorylation, cognitive loss, neural inflammation, oxidative stress or mitochondrial dysfunction, among others[68, 325]

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When data were not normally distributed the non-parametric tests such as the Mann-Whitney U-test or KruskalWallis analysis of variance were used