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Nevertheless, it remains unknown whether hydrochlorothiazide or thiazide-like diuretics reduce GLP-1 responses, glucose tolerance, energy intake behavior and feeding patterns in the long term

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Therefore, as an autoimmune disease, GD can cause systemic immune activation and high levels of inflammatory factors in the circulation, leading to the activation of the HPA axis and hypersecretion of related hormones

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It also has potent antioxidant and anti-inflammatory effects, reducing oxidative stress in gingival and joint tissue