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To investigate the role of nitric oxide signaling, mice received the nitric oxide synthase inhibitors N-Nitro-L-arginine methyl ester (L-NAME, 1 mg/kg) or aminoguanidine (AG, 200 mg/kg) prior to histamine administration

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Clinically, cutaneous MA occurs mainly in elderly white patients, its development is slow and usually shows roughened or papilllary surface

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