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In inflamed or diabetic wounds, keratinocytes, fibroblasts, and macrophages overexpress CD44, while the excessive accumulation of ROS generates a redox-imbalanced milieu analogous to tumor oxidative stress

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the researchers noted that sauna bathing improves endothelium-dependent vasodilation, reduces arterial stiffness, and modulates the autonomic nervous system toward parasympathetic dominance

Therefore, they look for ingredients for skin brightening, where Glutathione and Vitamin C take the lead