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J Hepatol (2018) 69(4):92747

Some people dont have any signs of a vitamin deficiency, while others have more severe symptoms

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Mechanistic studies suggest that the potential direct cardiovascular benefits of SGLT2i include augmentation of signal transducer and activator of transcription 3 (STAT3), inhibition of sodium hydrogen exchange (sodium-hydrogen antiporter 1 [NHE-1]), improved mitochondrial metabolism, modulation of natriuretic peptides, improved vascular stiffness and autonomic tone, reduction of inflammation, and improved cardiac energetics

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The relationship between GLP-1 therapy and biliary health requires careful evaluation, but having gallstones does not automatically rule out semaglutide use