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The activation of brain somatostatin signaling inhibits the colonic response to exogenously administered CRF or CRF endogenously released by stress (Stengel et al., 2011a)

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CYP1A2 displayed stable expression across Days 730, while CYP1B1 and CYP4F12 exhibited progressive increases, reaching maximum levels at Day 45, reflecting roles in fatty acid and bile acid metabolism during later stages

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