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Following demyelination, there is an overall increased demand for ATP ( + /K + ATPase pump were increased, due to redistribution and an overall increase in the number of Na + channels ( Shiverer mice exhibit a significant change in the density and activity of mitochondria in their axons in comparison to wild type animals (Millecamps and Julien, 2013)
It has been reported that the deficiency of TFEB increased the mitochondrial ROS production and exacerbate tubular injury during CP renal injury (Lynch et al., 2020)
Thyroid disease: Hormones made by the thyroid help manage many of our body processes, including some aspects of libido, such as energy and stamina