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Copper (Cu) is essential for the activation of superoxide dismutase (SOD, antioxidant defense), lysyl oxidase (collagen cross-linking), and wound-healing enzymes

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Moreover, enzymes involved in the antioxidant pathway (for instance, thioredoxin reductase) and GSH-producing pathway (for instance, glutathione synthetase and heterodisulfide reductase subunit C) were altered when gr was deleted or overexpressed in A

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Results: There were 594 upregulated and 90 downregulated proteins identified in the semaglutide cohort compared with control cohort