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Furthermore, DAG generated by PNPLA2 preferentially produces 1,3- DAG which cannot activate PKC (196), suggesting that the de novo generation of DAGs leads to insulin resistance

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Black C, Larson D, Rollberg B, A

The GLP-1 era does not invalidate those capabilities, but it requires something additional that the traditional pathway rarely develops

Yu P, Han W, Villar VA, Yang Y, Lu Q, Lee H, et al