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Investigational products in Phase 3 include orforglipron and retatrutide, neither of which is FDA-approved

FDA experts repeatedly stressed that adding the peptides to the section 503A bulk drug substances list would be a dangerous experiment, with physicians flying blind as far as dosing data and best prescription practices

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Figure 3: The average number of crossing into the target quadrant in each of the four different experimental groups included in the first part of the study