Heme oxigenase is part of the system which regulates the integrity of endothelial cells and which also regulates oxidative stress
EHMT2/G9a stood out as a potential target: it is an epigenetic regulator expressed in immune cells, including macrophages, and its previously determined half maximal effective concentration (EC 50 ) (PubChem AID: 504332) matches the effect range (10100 M) seen in our study 39
doi: 10.1093/lifemeta/loac035 98 SkoutaRDixonSJWangJDunnDEOrmanMShimadaKet al
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Consequently, users may notice improved skin brightness, a healthier glow, and more balanced skin tone over time