Importantly, increasing the endogenous production of GLP-1 by different mechanisms or by increasing the number of intestinal L-cells that tend to produce this hormone may be another effective therapeutic approach to managing T2DM
Some large database analyses have suggested a modest increase in pancreatitis risk, particularly in the first few months after initiation, while others have found no association after adjusting for confounding factors such as obesity, gallbladder disease, and alcohol use
There are a whole class of medications that are insulin sensitizers, so perhaps we can develop medications that will allow people to be sensitized to GLP-1s or find formulations of GLP-1, like the longer-acting versions, that avoid the GLP-1 resistance. Anna Gloyn A key function of GLP-1 and drugs that mimic it is to slow the passage of food through the stomach, known as gastric emptying, which helps with both glucose regulation and weight loss
Retrieved July 12, 2026
Secretion of incretin hormones (GIP and GLP-1) and incretin effect after oral glucose in first-degree relatives of patients with type 2 diabetes
If you stop, you gain back the lost weight
