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Clinical studies show patients lose an average of 15% of their body weight in one year thats 30 pounds for someone who weighs 200 lbs

This goes directly against the mantra of informed consent," said study author Mohit Sodhi

The initial dose of thyroxine is decided according to body weight, and thereafter adjusted according to the results of the blood tests of thyroid function

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A HOMER motif enrichment analysis identified potential regulatory factors driving these transcriptional changes, with transcription factors for upregulated genes including FOXO3, OCT4, and TBX5, and those for downregulated genes including HRE, NPAS4, and TWIST ( Figure S6E )