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Initial treatment for B12 deficiency with neurological involvement: When elderly patients present with neurological symptoms (peripheral neuropathy, cognitive impairment, subacute combined degeneration of the cord), urgent and aggressive replacement is essential to prevent irreversible damage

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Topical can be run continuously

A severely degenerated rotator cuff in a 65-year-old with decades of wear will not become a healthy 25-year-old tendon

Both statements are factual regulatory information, not recommendations

Its a fundamentally different philosophy of skin rejuvenation, focusing on restoring youthful function rather than just treating surface-level signs of aging