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Further studies confirmed its capability to promote macrophage polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype

developed a novel hypoxia-activated combination nanomedicine that targets hypoxic tumors through hypoxia-sensitive block copolymers and photothermal/photodynamic therapy (PTT/PDT), efficiently delivering drugs and achieving synergistic anticancer effects of chemotherapy and PDT/PTT, completely eliminating advanced breast cancer, including hypoxic and metastatic tumors, stimulating a systemic antitumor immune response, and significantly improving survival rates, showing important clinical application potential [500]

402 CBP/p300 Using the ovarian cancer cell line SKOV3, it has been reported that Staphylococcal nuclease domain-containing protein 1 (SND1) regulates the gene transcriptional activation of SLUG (an epithelial-to-mesenchymal transition marker) by increasing chromatin accessibility through the recruitment of the acetyltransferases GCN5 and CBP/p300 to the SLUG promoter proximal region

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L-carnitine allows the correct oxidation of fatty acids and thus the release of energa.Se ensures that fats are used as an energy source

Loss of Glp2r signaling activates hepatic stellate cells and exacerbates diet-induced steatohepatitis in mice