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Pharmacokinetic Profile Route of Administration Subcutaneous Dosing Frequency Once weekly Half-Life 5 days Route of Administration : Subcutaneous injection Dosing Frequency : Once weekly Half-Life : ~5 days Formulation : Lyophilized powder for reconstitution Formulation & Handling Store at 20C Protect from light and moisture Reconstitute with sterile water

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About 42% of people in the US meet the CDCs definition of obesity

Fluoroquinolones (ciprofloxacin, levofloxacin) carry rare risks of severe hypoglycemia

No acute or chronic effects on systolic blood pressure were observed in DIO mice receiving twice-daily oral PL7737 at 20 mg/kg for two weeks, suggesting the compound lacks the cardiac effects observed in other melanocortin compounds (136)