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Treatment with high dose vitamin B12 been shown to be safe for more than 50 years Out of fear of overdosing vitamin B12, treatment is often reduced to below the frequency that is needed by the patient, or, even worse, treatment is stopped completely

2002;30(Pt 6):879-82

Vitamin b12 injections are the most common way to prevent or treat a deficiency

Some providers split the dose into two smaller injections per day (morning and evening) for sustained signaling, though once daily is most common

J.FrutosM

The oral capsule format is of particular interest in this area, since the swallowed peptide is delivered directly into the gastrointestinal tract, where much of this research activity has historically been localised and where the compounds reported stability in gastric conditions is most relevant