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Continued treatment with tirzepatide is necessary to maintain weight loss

10.1016/j.biopsych.2016.08.024 10

doi: 10.1161/CIRCRESAHA.116.308999

Obesogen-induced dysregulation of lipid homeostasis primarily occurs through the activation of nuclear transcriptional regulators, such as the peroxisome proliferator-activated receptor gamma (PPAR-) and retinoid X receptor (RXR) heterodimer, which favours adipocyte proliferation and differentiation, and, consequently, enhances its functionality [10, 13]

In contrast, almost half of included studies showed no statistically significant improvement in glycemic status [19, 20, 22,23,24, 26, 29, 31]

Molecular Probes, Eugene, OR, USA) dyes live cells while bis(1,3dibutylbarbituric acid) trimethine oxonol (DiBAC