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A first-in-human, randomized, double-blind study of safety and pharmacokinetics in adults suggested that NYX-2925 was safe and well tolerated

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6 June 2023

Canonico et al., 2023)

In laboratory studies, GLP-1 RAs decrease de novo lipogenesis by down-regulating SREBP-1c and up-regulating AMPK, enhance -oxidation through PPAR- activation, and reduce oxidative stress through cAMP-PKA-mediated pathways [21, 24]

20 However, a retrospective single-institution study showed that although other anti-diabetic medications (such as sodium-glucose cotransporter 2 inhibitors) were associated with a lower risk of sight-threatening DR, GLP-1RAs were not shown to confer any increased DR risk, clinical worsening, or increased intervention in DR