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FAD is required by -ketoglutarate-dependent dioxygenasessuch as TET DNA demethylases and JmjC family histone demethylaseseither directly or indirectly via metabolic interactions (69)

Furthermore, ApoE isoforms, particularly ApoE4, demonstrate involvement in -synuclein aggregation, TDP-43 and FUS-induced neurodegeneration, HTT gene regulation, MS susceptibility, and disruption of BBB