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FEMS Microbiology Letters , 370, fnad116

Another approach involves intrastriatal infusion of an adeno-associated viral vector containing the gene for human aromatic L-amino acid decarboxylase, which has been reported in a phase I safety trial

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This phenomenon is thought to be due to the inability of cells to restore normal GSH levels or to increased production of reactive oxygen species (ROS), which can damage macromolecules fundamental to cell survival before being deactivated by antioxidant defenses