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For instance, butyratea key microbial metaboliteenters the circulation and attenuates pro-inflammatory cytokine secretion primarily through the inhibition of histone deacetylase (HDAC) activity (Wang et al., 2024)

Gradual tapering (reducing dose over 4-8 weeks) may reduce appetite rebound intensity compared to stopping abruptly, though both approaches carry weight regain risk

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McCormick WJ

Mistry J, Chuguransky S, Williams L, Qureshi M, Salazar Gustavo A, Sonnhammer ELL, et al

During the bioleaching process, the released heavy metals are toxic to the leaching microorganisms, and the stress tolerance process of the microorganisms will result in the production of reactive oxygen species (ROS) inside the cells (Stadtman and Oliver, A