Vaduganathan M, Mensah George A, Turco Justine V, Fuster V, Roth GA
In addition to being administered as a drug to cause oxidative stress, MTX has also been used to induce cachexia, anorexia, intestinal mucositis and digestive absorption problem in experimental animal models (Reference Boukhettala, Leblond and Claeyssens34Reference Sinno, Coquerel and Boukhettala36)
Individuals with increased screen exposure
In fact, about 40% of people (based on female trials) experienced nausea after a 1.75 mg dose, compared to only ~1% on placebo
Am J Hum Genet (2019) 105:23757
This involves not only identifying and mitigating current risks but also examining how different risks may interact and amplify one another