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Common symptoms of B12 deficiency include heart palpitations, shortness of breath, and swelling in the ankles and feet

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It has been used to treat neurological diseases such as Huntingtons chorea, Tourettes disease, cerebellar ataxia and certain types of seizures

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The research rationale for a selective NNMT inhibitor is to interrupt exactly that diversion, so the cell keeps more of its NAD+ pool and can run its mitochondrial machinery again

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