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For European DR patients carrying these genetic variants, GLP-1RAs may be prioritised, with close monitoring of their efficacy in improving retinopathy

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Some patients report improvements in sexual function and libido during semaglutide treatment, potentially related to weight loss, improved self-confidence, better glycemic control, and enhanced cardiovascular function

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Acknowledgements The authors thank the financial support by the National Natural Science Fund of China (31772859 and 31830102) and Program of Shanghai Academic Research Leader (19XD1421200)

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