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The indirect mechanisms consist of modulating gene expression and intracellular signaling pathways, promoting the activation and synthesis of endogenous antioxidant enzymes [38]

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Ultrastructure analysis shows that when ferroptosis occurs,cell membrane rupture and bubbles occur, mitochondria decrease, mitochondria atrophy, the mitochondrial spine decreases or even disappears, and mitochondrial membrane density increases, possibly due to dysfunction of varistor anion channels (VDACs) and alterations in the fluidity of mitochondrial membranes [45]

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