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(PubMed) Heitzer T, Finckh B, Albers S, Krohn K, Kohlschutter A, Meinertz T

Severe breathing difficulty, chest pain, confusion, very high fever with shaking chills, inability to keep fluids down for over 24 hours, or signs of severe dehydration all need in-person medical evaluation first

Hyperpigmentation: 4% niacinamide reduces melasma severity, and 5% formulations show tone improvement when paired with antioxidants and tranexamic acid

This route carries a higher risk of certain side effects: 5,7,8 Allergic reactions: Hives, swelling, difficulty breathing, or severe skin reactions (e.g., Stevens-Johnson syndrome)

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