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Methods Search strategy Extensive literature search was performed for articles in PubMed and Google Scholar databases until July 13, 2025

Dose: 50mcg per day

Clinical evidence: A 12-week RCT of 60 participants showed that a Mediterranean diet rich in fish reduced Depression Anxiety Stress Scales (DASS) stress score by 145%

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CYP2A6 mRNA and protein expression, along with CYP2A6 enzyme activity, vary more than 50-fold among individuals (107)