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People who have to lose more weight to get to their goal, for example, 100 pounds vs 20 pounds, are more likely to have noticeable changes

Their joint consensus statement concluded that the existing literature indicates a possible small increased risk of NAION in patients taking semaglutide, but the risk remains low and is yet to be confirmed

doi:10.3892/etm.2018.6406 So SY, Savidge TC

Incretin hormones, gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), both play important roles in triggering the pancreas to secrete insulin to achieve normal glucose homeostasis, however, for people with diabetes, the pancreas becomes less responsive to incretins (predominately to GIP)

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