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Rare side effects: Allergic reaction (rash, swelling, dizziness)

It has been suggested that the accumulation of D-2-hydroxyglutaric acid may contribute to impaired mitochondrial energy metabolism, increased oxidative stress, activation of N-methyl-D-aspartate (NMDA) receptors, and increased glutamate uptake, which may have toxic effects on cells and nerves [54], leading to the occurrence of epilepsy

Understanding how the active forms of these vitamins, specifically methylcobalamin and L-5-methyltetrahydrofolate (L-5-MTHF), support the body at a molecular level can provide a validating framework for managing the complex symptoms of Long COVID and ME/CFS

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dose escalation should always be done under medical supervision

Implementing advanced methods before addressing basics wastes effort and can create unnecessary complexity