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Response: We appreciate the commenter's recommendation regarding the APC assignment of CPT code 52597 (0421T) but we disagree that the clinical complexity and resource required for CPT code 52597 (0421T) is comparable to CPT code 55882

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3 Extended Administration Pharmacokinetics in DIO Mice Neelakantan et al., Biochemical Pharmacology (2024) This study reported a 28-day once-daily administration protocol of 5-Amino-1MQ in diet-induced obese mice, characterizing plasma pharmacokinetics, tissue distribution, and effects on body composition, fatty liver pathology, and circulating biomarkers

Translating a 50% reduction in healing time from rats to humans requires pharmacokinetic validation that doesn't exist