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Abstract Glucagon-like peptide-1 (GLP-1) has a broad spectrum of biological activity by regulating metabolic processes via both the direct activation of the class B family of G protein-coupled receptors and indirect nonreceptor-mediated pathways

A study of the rats behavior in a field

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The dual mechanism is the most plausible explanation for the larger average effect, but "plausible explanation for a group difference" is a much weaker claim than "will work better for you." Response varied enormously within both arms of SURMOUNT-5, which is why the trial reported the proportion of participants hitting each threshold rather than a single expected result

The cellular dysfunction of the brain-blood barrier from endothelial cells to astrocytes: the pathway towards neurotransmitter impairment in schizophrenia

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