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GHK-Cu, the copper peptide that stimulates collagen synthesis and wound healing, requires higher doses to achieve therapeutic effects

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Neuronal degeneration was associated with decreased immunostaining for microtubular-associated protein-2 (MAP2) in dendritic branches, synaptophysin in presynaptic boutons and neurofilaments in nerve fibers

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doi: 10.1001/archpedi.1993.02160340087020

Mechanistically, SAC directly interacts with Keap1 to promote Nrf2 into the nucleus, enhance the transcription of antioxidant genes (such as GPX4 and NQO1), and restore the biosynthesis of GSH