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However, GSH has an overall negative charge at physiological pH, and mitochondria also exhibit an enormous negative membrane potential [57, 58]

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Unlike observations by Klukov et al

Laboratory detection of Haemophilus influenzae with decreased susceptibility to nalidixic acid, ciprofloxacin, levofloxacin, and moxifloxacin due to GyrA and ParC mutations

Most tumor cells undergo aerobic glycolysis not OXPHOS for energy supply, even under sufficient oxygen conditions, a mechanism known as the Warburg effect, to meet their unique energy and material metabolism needs