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Lack of FDA approval and standardized clinical data limits confirmed use in medical practice despite promising preclinical findings

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HCG exerts its effects by binding to luteinizing hormone (LH) receptors on target cells in the ovaries and testes, thereby mimicking the action of endogenous LH

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Therefore, to further dissociate the effects of GSH and NRF2 on lipid abundance and assess if NRF2 activation alone mimics the effects of liver-specific Gclc deletion, we treated Gclc WT mice with CDDO-methyl (CDDO-Me), a form of bardoxolone with increased bioavailability

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