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The bottom line: Our findings suggest that GLP-1RA and SGLT2i (and especially SGLT2i with the lowest number needed to treat (NNT) for nearly all study outcomes) may be the preferred glucose-lowering agents for cardiovascular risk reduction in patients at moderate risk for CVD, building on and consistent with existing RCT evidence in the high-risk population. This report highlights potential preference for GLP-1 drugs as a first-line treatment for Type 2 diabetes related to its cardioprotective effect

Others are looking at alternative ways to stabilise GLP-1 drugs that might prove easier to produce

Front Cell Neurosci 30(15):654340 Khanahmadi M, Manafi B, Tayebinia H, Karimi J, Khodadadi I (2020) Downregulation of Sirt1 is correlated to upregulation of p53 and increased apoptosis in epicardial adipose tissue of patients with coronary artery disease

If you smoke and consume alcohol then avoid them at least 2 weeks before treatment

Diabetologia 58 (Suppl

Restraints Impact Analysis Regulatory scrutiny of promotion: Authorities are challenging misleading claims about compounded GLP-1 products and product equivalence