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Most evidence extrapolated from other tissues

Sensitive skin may do better with slower introduction or lower-strength products

An estimated 3-12% of people treated with opioids for chronic pain will develop an addiction or abuse with negative consequences.(12) Approximately 8.6 million Americans reported misusing prescription opioids in 2023.(13) People who develop tolerance or dependence to prescription opioids may transition to illegally produced opioids, such as a fentanyl

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As BAC increases: At around 0.05%, individuals may experience uninhibited behavior and decreased alertness