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Although the GLP-1R has low affinity for GLP-1 936 amide, compound 2 enhances its potency for cAMP generation by 100-fold in HEK-GLP-1R cells

Additionally, case studies have shown that while GLP-1 medications can lead to weight loss, 40-60% of this loss might come from lean mass, which necessitates careful management to prevent muscle loss and maintain strength

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