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Safety: Start with low doses and go slow to minimize GI side effects

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They say there may be two factors: Significant weight loss can reduce body inflammation and metabolic health, both important for pregnancy

Begin with a comprehensive thyroid workup, optimize hormone therapy, and introduce GLP-1s gradually if appropriate.

Avoid ultra-processed foods, high-fat takeout, and refined carbohydrates, which are harder to digest on semaglutide and often trigger nausea or bloating

(131) noticed the absence of the liver kinase B1 protein (LKB1), which plays a crucial role as the primary enzyme responsible for enabling the phosphorylation of AMPK (132), greatly reduces the breakdown of fatty acids in mice during physical exercise and in isolated muscle contractions outside the body, indicating that LKB1 plays a vital role in muscle fatty acid oxidation during activity, independent of AMPKs effect (131)