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While the marketing authorisation covers BMI 30 kg/m or 27 kg/m with weight-related comorbidities, NHS prescribing follows NICE Technology Appraisal criteria, which are more restrictive

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It cites a 2015 meta-analysis of 14 randomised controlled trials finding consistent but modest HbA1c reductions, while noting many trials lacked rigorous controls and that publication bias toward positive findings is likely

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This could be due to: Nutritional Gaps: You may not be consuming enough of the amino acids (cysteine, glycine, glutamate) or cofactors (selenium, B-vitamins, Vitamin C) required to build glutathione

The pain was persistent, and I often felt stiffness and discomfort that would last for days