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Reading Each Dose on the Ladder Trial and clinical protocols seek the lowest dose that keeps the relevant markers moving without unacceptable side effects

Due to its electrophilic nature, 4-HNE interacts with cysteine, histidine, and lysine residues in proteins, forming Schiff bases and Michael adducts that exhibit pro-oxidant, pro-inflammatory, and pro-apoptotic properties

Am J Clin Nutr 1990;52(5):889-894

Handling: Allow frozen vials to reach room temperature before opening to minimize condensation

Schaffer, C.J

[PMC free article] [PubMed] [Google Scholar] Aliev G., Liu J., Shenk J.C., Fischbach K., Pacheco G.J., Chen S.G., Obrenovich M.E., Ward W.F., Richardson A.G., Smith M.A., Gasimov E., Perry G., Ames B.N