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The ideal racing pigeon is one that combines fitness with sufficient energy reserves

Specifically, sphingomyelinases (also known as sphingomyelin phosphodiesterases) catalyze the cleavage of sphingomyelin, generating phosphocholine and ceramide

Disruption of ERAD in this context impairs leptin responsiveness, resulting in hyperphagia, excessive weight gain, and heightened susceptibility to diet-induced obesity in mice

USA 108 , 30473052 (2011)

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