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Among people who were celebrating joining the 100-pound club and swapping tips to combat nausea or relieve constipation, there were dozens describing the same feeling I had no highs, no lows, a feeling of living in some strange middle land

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Oxidative stress induces senescence in chondrocytes

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That part of my brain is just shut off, she said, adding she also no longer feels the effects of alcohol when she drinks, so she tends to skip out on wine, which she calls empty calories.