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One in vivo study assessed the effect of KD on the progression and metastatic development of cutaneous melanoma (222)

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In light of the partly opposing effects of GIP on insulin secretion and on fat deposition, we have doubts whether either agonists or antagonists at the GIP receptor will play a therapeutic role [11]

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Estimated hazard ratio for 6 mg/weekly dose of efpeglenatide compared to placebo was 0,65 (95% CI, 0.5 to 0.86) and 0.82 (95% CI 0.63 1.06) for 4 mg/weekly dose compared to placebo (44)