Recently, a systematic review and meta-analysis clearly demonstrated the superiority of regenerative treatment of intrabony periodontal defects compared to access flap alone [10]
On the other hand, another theory is that the rapid weight loss caused by these agents may trigger telogen effluvium, a type of non-scarring alopecia characterized by widespread hair shedding, typically seen after metabolic stress
Res Commun Chem Pathol Pharmacol 38:5770 Black M, Raucy J (1986) Acetaminophen, alcohol, and cytochrome P-450
they didn't treat the issue, or they had untenable side effects)
The practical consequence: when in doubt, community sources cite using more bac water rather than less
10.1016/j.thromres.2012.03.014 Thromb Res