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Additional factors include some prescription drugs, diabetes, rheumatoid arthritis and poor thyroid function as well as with chronic inflammatory diseases in general, and some intestinal disorders such as coeliac and Crohns diseases

Gastrointestinal Effects The most commonly reported adverse effects are gastrointestinal in nature, including: Nausea and vomiting (affecting 20-40% of patients initially, varying by agent and dose) [8] Diarrhoea or constipation Abdominal discomfort and bloating Reduced appetite In elderly patients, persistent nausea and vomiting can lead to dehydration and electrolyte imbalances more rapidly than in younger adults

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Nutrients 13 (7)